Is Hormone Replacement Therapy Safe in Women With a BRCA Mutation?

I have had many women concerned that they cannot have HRT due to being BRAC +ve, so they have had to suffer needlessly from the symptoms of menopause. This study can allay their fears
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Am J Clin Oncol. 2016 Feb 2. [Epub ahead of print]

Is Hormone Replacement Therapy Safe in Women With a BRCA Mutation?: A Systematic Review of the Contemporary Literature.

Birrer N1, Chinchilla C, Del Carmen M, Dizon DS.

Author information

Abstract

OBJECTIVES:

Women with a BRCA1 or BRCA2 mutation are recommended to undergo prophylactic (or risk reducing) bilateral salpingo-oophorectomy (BSO) before age 40, resulting in surgical menopause. Given the concerns of estrogen deprivation on overall health, hormone therapy (HT) is often discussed, yet safety concerns persist.

MATERIALS AND METHODS:

We performed a systematic literature review of the safety of HT in women with a BRCA mutation undergoing prophylactic BSO.

RESULTS:

Although there remains a paucity of data on this topic, as evidenced by this systematic review of the contemporary literature, these patients do benefit from treatment, especially as it relates to menopausal symptoms without an apparently increased risk of breast cancer.

CONCLUSIONS:

Decisions regarding the use of HT in women who undergo BSO after detection of a BRCA mutation must be individualized based on careful consideration of the risks and benefits. However, the risks of a subsequent cancer diagnosis appear small, particularly in regards to the benefits of treatment afforded by HT

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